The famed master builder Jonathan Goldsmith designed and built this well-proportioned federal style residence in 1829 for Dr. John H. Mathews. It is considered to be one of the finest Goldsmith houses. The house was moved to its present location on the campus of Lake Erie College from the original North State Street site in 1949 and was registered with the Ohio Historical Society in 1965.
Today, the Mathews House serves as a guest house for alumni as well as other esteemed visitors. It was completely redecorated in 2008.